Jonathan D. Tew A mechanistic approach to developing spherical agglomeration for process intensification in pharmaceutical manufacturing
September 2016 - 2021
Contact: Sir Robert Hadfield Building, Mappin St, Sheffield, S1 3JD firstname.lastname@example.org
Biography I completed an integrated Master's in Bioengineering at The University of Sheffield in 2016. I received First Class Honours with a specialism in Biomanufacturing. My MEng project involved preliminary work in the liquid-liquid separation of proteins from a cell media, in a technique called aqueous two phase extraction. I was supervised by Professor Robert Falconer, formely of this department.
During my studies, I played significant roles in the guiding of Learning Teaching, at a course-wide, faculty-wide, and university-wide level. I was recognised for outstanding contribution in these areas for the 2014/2015 academic year. In my PGR studies, I have taken on a wider role of encouraging Mental Health awareness and support at a Faculty-wide level.
Research My research project focuses on the process of spherical agglomeration, which can be used to beneficially tailor the properties of active pharmaceutical ingredients. I will be specifically focusing on the nucleation/wetting and growth/consolidation rate processes and how these affect the formation of agglomerates. I will be using an oscillatory baffled reactor and particle viewing and measurement probe to study these effects on crystal particles, with the aim of using modelling tools to accurately predict process performance. I am funded through the CMAC Hub based at The University of Strathclyde (EPSRC Grant). I am also currently collaborating with Imperial College London on a paper for modelling approaches for ternary solvent systems.