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Jonathan D. Tew
A mechanistic approach to developing spherical agglomeration for process intensification in pharmaceutical manufacturing

September 2016 - Present
Contact:​
Sir Robert Hadfield Building, Mappin St, Sheffield, S1 3JD
jtew1@sheffield.ac.uk
Biography
I completed an integrated Master's in Bioengineering at The University of Sheffield in 2016. I received First Class Honours with a specialism in Biomanufacturing. My MEng project involved preliminary work in the liquid-liquid separation of proteins from a cell media, in a technique called aqueous two phase extraction. I was supervised by Professor Robert Falconer, formely of this department.

During my studies, I played significant roles in the guiding of Learning Teaching, at a course-wide, faculty-wide, and university-wide level. I was recognised for outstanding contribution in these areas for the 2014/2015 academic year.  
​In my PGR studies, I have taken on a wider role of encouraging Mental Health awareness and support at a Faculty-wide level. 

Research
My research project focuses on the process of spherical agglomeration, which can be used to beneficially tailor the properties of active pharmaceutical ingredients. I will be specifically focusing on the nucleation/wetting and growth/consolidation rate processes and how these affect the formation of agglomerates. I will be using an oscillatory baffled reactor and particle viewing and measurement probe to study these effects on crystal particles, with the aim of using modelling tools to accurately predict process performance. ​I am funded through the CMAC Hub based at The University of Strathclyde (EPSRC Grant). I am also currently collaborating with Imperial College London on a paper for modelling approaches for ternary solvent systems. 

Publications
  • Arjmandi-Tash, O., Tew, J.D., Pitt, K., Smith, R., Litster, J.D. (2019). A new mathematical model for nucleation of spherical agglomerates by the immersion mechanism. Chemical Engineering Science X. 4, 100048.
  • Pitt, K., Peña, R., Tew, J.D., Pal, K., Smith, R., Nagy, Z.K., Litster, J.D. (2018). Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling. Powder Technology. 326, 327-343.


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The Department of Chemical and Biological Engineering
Sir Robert Hadfield Building
The University of Sheffield
Mappin Street,
​Sheffield, S1 3JD
  • Home
  • Research Themes
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  • Our Group
    • Academics
    • Post-Doctoral Researchers
    • PhD Researchers
    • Affiliated Members
    • Alumni
    • Summer Students
  • Current Opportunities
  • Get in Touch